Development and Evaluation of Elaeagnus rhamnoides (L.) A. Nelson Oil-Loaded Nanostructured Lipid Carrier for Improved Skin Hydration

Sea buckthorn (SB) (Elaeagnus rhamnoides (L.) A. Nelson) is rich in flavonoids, phenolic compounds, anthocyanins, carotenoids, and phytosterol. Its phytochemicals exhibit various biological activities, such as antioxidant, immunomodulatory anti-carcinogenic activities. SB also helps prevent the development of wrinkles protects skin’s surface from UV rays. The purpose present study was to develop characterize an oil (SBO)-loaded nanostructured lipid carrier (NLC) for improved skin hydration. response methodology (RSM) central composite design (CCD) were employed optimize influencing factors (wax percentage, surfactant PEG400 percentage surfactant) achieve desirable qualities SBO-NLCs. optimum (minimum) size SBO-NLCs (105.26 nm) obtained with a combination 2.5% wax, 7.5% surfactant, 30% surfactant. A narrow polydispersity index (PDI; 0.16), relatively low zeta potential (ZP; −15.63 mV), high entrapment efficiency (EE; 90.88%) observed this study. Reduced quadratic reduced 2FI models adapted predict conditions attain PDI SBO-NLCs, respectively. ZP EE predicted help cubic model. All statistically significant. Differential scanning calorimetry results suggested that had less crystallinity therefore rate drug expulsion inner core NLCs. noticeable level occlusion effect showed faster vitamin E (biomarker drug) release into within 24 h, released after 48 h significantly higher than free SBO. Additionally, delivered (22.73 ± 1.67 µg/cm2 skin). In conclusion, SBO-NLC delivery system can be used water loss improve Further investigations, stability safety evaluations, are required prior commercialization human use.